10.30-10.45 Adam Shellard
University College London, UK
“The forgotten rear of collective cell migration: a new role for supracellular contractility”
Collective cell migration (CCM) requires a front/back polarity, yet little is known about the processes at the rear. We show that the neural crest cell group, a model of CCM, has an actomyosin ring that contracts supracellularly. During migration, contractility is inhibited at the front but persists at the rear. This anisotropic contractility is necessary and sufficient to drive collective cell migration, can be reproduced in silico, and can be explained mechanistically by cell intercalation from the rear. These findings show for the first time an active role of rear cells in controlling CCM.