14.00-14.15 Laura Mara Mueller
Max Delbrück Center for Molecular Medicine, Berlin, Germany
“Study of novel molecular defects in human pancreas dysfunction”
Unelucidated forms of monogenic diabetes, arising from rare mutations in one single gene, represent invaluable models for identifying new targets of pancreatic β-cell development and function. My PhD project focuses on putative disease-causing mutations identified by next-generation sequencing of a large cohort of patients with puberty-onset diabetes. By combining directed human induced pluripotent stem cell (iPSC)differentiation with gene editing, I generated a platform to investigate the role of the gene candidates and mutations in pancreatic cell fate decisions and cell function.